My PhD is a translational project between natural product chemistry, drug discovery and cancer biology.
This work aims to study new cytotoxic compounds from Australian endemic plants. I have gained skills in a wide range of chemical techniques (e.g. HPLC, MPLC, 1D/2D NMR, UV, IR, and MS),which has led to the isolation and characterisation of several new and exciting natural products, some of which display potent in vitro inhibition of prostate cancer cells (IC50 in the nM range). Furthermore, I have taken these unique compounds and conducted mechanism of action studies using chemical biology techniques such as DNA microarray, live cell imaging, cell cycle analysis, Western Blot and immunofluorescence microscopy.